2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

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Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that metabolize endogenous and exogenous aldehydes to corresponding carboxylic acids. This superfamily of proteins is comprised of 19 isozymes, with constitutive activity of at least one isozyme observed in a majority of mammalian tissues. The ALDHs play important roles, among other things, in cellular detoxification, the protection against ultraviolet radiation-induced damage, and amino acid metabolism.

The ALDH1A subfamily plays a pivotal role in embryogenesis and development by mediating retinoic acid signaling. ALDH2, as a key enzyme that oxidizes acetaldehyde, is crucial for alcohol metabolism. ALDH1A1 and ALDH3A1 are lens and corneal crystallins, which are essential elements of the cellular defense mechanism against ultraviolet radiation-induced damage in ocular tissues. Many ALDH isozymes are important in oxidizing reactive aldehydes derived from lipid peroxidation and thereby help maintain cellular homeostasis. Increased expression and activity of ALDH isozymes have been reported in various human cancers and are associated with cancer relapse. As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases.

Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

Aldehyde Dehydrogenase (ALDH) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-144667
    ALDH1A3-IN-1
    		Inhibitor 98.43%
    ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 μM and a Ki of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer.
    ALDH1A3-IN-1
  • HY-144669
    ALDH1A3-IN-2
    		Inhibitor 99.28%
    ALDH1A3-IN-2 (Compound 15) is a potent inhibitor of ALDH1A3 with an IC50 of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH1A3-IN-2 has the potential for the research of cancer diseases.
    ALDH1A3-IN-2
  • HY-146683
    KS106
    		Inhibitor 99.31%
    KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.
    KS106
  • HY-156443
    YG1702
    		Inhibitor 99.21%
    YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity.
    YG1702
  • HY-110294
    CM037
    		Inhibitor 99.06%
    CM037 is a selective inhibitor of ALDH1A1 (aldehyde dehydrogenase 1A1) with an IC50 of 4.6 µM.
    CM037
  • HY-135841
    CM010
    		Inhibitor 98.07%
    CM010 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM010 does not inhibit any of the other ALDH family members. CM010 can regulate metabolism and has anti-cancer activity.
    CM010
  • HY-122912
    ALDH1A inhibitor 673A
    		Inhibitor 99.15%
    ALDH1A inhibitor 673A is an ALDH1A inhibitor. ALDH1A inhibitor 673A inhibits all three ALDH1A family members (IC50: 246 nM, 230 nM, 348 nM for ALDH1A1, ALDH1A2, ALDH1A3 respectively. ALDH1A inhibitor 673A induces necroptotic cell death preferentially in CD133+ ovarian CSCs. ALDH1A inhibitor 673A also inhibits chemotherapy-resistant tumor growth.
    ALDH1A inhibitor 673A
  • HY-112277
    NCT-505
    		Inhibitor 99.37%
    NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM).
    NCT-505
  • HY-146682
    KS100
    		Inhibitor 99.61%
    KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.
    KS100
  • HY-125085
    ALDH3A1-IN-3
    		Inhibitor 99.30%
    ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM. ALDH3A1-IN-3 has no inhibitory potential on the in vitro activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2. ALDH3A1-IN-3 can be used in cellular oxidation and cancer research.
    ALDH3A1-IN-3
  • HY-122577
    EN40
    		Inhibitor 99.56%
    EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM
    EN40
  • HY-126003
    ALDH1A1-IN-2
    		Inhibitor 99.31%
    ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295).
    ALDH1A1-IN-2
  • HY-107030
    Nitrefazole
    		Inhibitor 99.44%
    Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.
    Nitrefazole
  • HY-76006
    3-Hydroxybenzaldehyde
    		99.89%
    3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis.
    3-Hydroxybenzaldehyde
  • HY-B0240R
    Disulfiram (Standard)
    		Inhibitor
    Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu2+ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells[1-6].
    Disulfiram (Standard)
  • HY-W007330
    2-Bromoacetamide
    		Inhibitor 99.71%
    2-Bromoacetamide can inactivate alcohol dehydrogenase.
    2-Bromoacetamide
  • HY-113466S
    4-Hydroxynonenal-d3
    		Inhibitor ≥99.0%
    4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
    4-Hydroxynonenal-d<sub>3</sub>
  • HY-148243
    IGUANA-1 free base
    		Inhibitor 99.69%
    IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer.
    IGUANA-1 free base
  • HY-157567
    FSI-TN42
    		Inhibitor 98.05%
    ALDH1A1/2-IN-1 is an ALDH1A1 and ALDH1A2 inhibitor that can be used for preventing spermatogenesis.
    FSI-TN42
  • HY-118980
    Sorbitol dehydrogenase-IN-1
    		Inhibitor 98.70%
    Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol.
    Sorbitol dehydrogenase-IN-1
Cat. No. Product Name / Synonyms Application Reactivity
Aldehyde Dehydrogenase (ALDH) Isoform Comparison

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